Table Of Content
In other cases, product advancement occurred as a result of significant co-development between HHT and the client and/or through the licensing of NRC intellectual property or enabling technologies. The examples below present information drawn from some of the evaluation case studies and illustrate HHT 's Footnote 35 contributions in these areas. In this regard, many interviewees and experts observed that the best mechanism for showcasing HHT /client success stories is through NRC and third party press releases. While most internal interviewees agreed on the importance of press releases, many perceived the process of getting an official NRC press release approved as being extremely complex. They highlighted past difficulties in getting press releases issued even after significant time and effort had been expended. In response to this, NRC Communications Branch staff reported that although certain difficulties may have been experienced in past years, processes with respect to the issuance of NRC press releases have recently been improved.
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As will be described in Section 4.2, HHT has established a major collaborative relationship with Zymeworks Inc., which has proven to be extremely beneficial for both parties. In addition to the impacts noted above, the evaluation found that, through its work with PnuVax, HHT has also contributed to strengthening of Canada's biomanufacturing capabilities. “The Museum of Innocence" by Orhan Pamuk. It is the most incredible love story based in Istanbul. There is an actual museum in the city that is dedicated to this love story. It is incredibly moving, and I visit every time I travel to Istanbul. Our creations are everyday heirlooms, designed to be worn daily and loved for a long time. Over the years, our products have become staples in the closets of thoughtful, stylish men and women worldwide, who appreciate the delightful combination of outstanding quality, everyday comfort, and the use of beautiful textiles in charming, unconventional ways.
1 Evaluation Overview
This includes, for example, its work in developing the Research, Development and Innovation Vaccine Federal Action Plan, as well as collaborative research agreements with federal, academic and not-for-profit partners. With limited funding available, SME s can face challenges overcoming the industry's initial "valley of death". Footnote 19 As part of the evaluation, client interviewees were asked what needs their companies were looking to address through their interactions with HHT .
Appendix B: HHT logic model
More importantly, HHT appears to be well positioned to continue to achieve impacts in the future. Portfolio management have adopted a culture of continuous improvement and are revisiting internal processes and approaches to ensure that HHT operations are both effective and efficient. In performing this comparison, the evaluation team worked closely with HHT and Finance Branch staff to ensure that the two time periods considered similar expenditure and revenue types and could therefore be reasonably compared.
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In addition, revenues represented 33% of salary and operations and maintenance ( O&M ) in 2013‑14, as compared to 19% in 2011‑12. The HHT Portfolio aligns well with federal priorities and NRC strategic outcomes, given its focus on industry-relevant R&D and its intended contribution to healthcare. HHT activities and expected outcomes are consistent with federal roles and responsibilities. As part of the TBBB Program, HHT is currently working with a handful of MNE partners, coupling their CNS therapeutics with NRC carriers to reach proof of mechanism, thereby validating the effectiveness of the NRC carriers.
Footnotes
Footnote 28 The second portfolio-level outcome demonstrates how, in the long-term, HHT seeks to contribute to alleviating growing healthcare pressures, which has been identified as a critical issue in NRC strategic documents. For 2013‑14, HHT reported total expenditures (direct and indirect) of approximately $49.1M. Approximately 25% of these expenditures were offset by earned revenues ($12.3M), which were derived mainly from strategic research projects with industry (see Table 2, on the following page). This evaluation was led by an independent evaluation team from the NRC Office of Audit and Evaluation ( OAE ). The work of the evaluation team was supported by Methodological and Subject-Matter Experts ( MSE s) who provided advice related to the evaluation framework, approach, interpretation of findings and recommendations.
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Whereas experts for the Biologics Program had a very positive view of that program's alignment with industry needs, the views of expert reviewers for the Vaccines Program were more mixed. Two of the three experts for Vaccines noted that the services and competencies available through the Program are meeting industry needs to a slight or moderate extent, while the third reported that the Program is addressing industry needs to a considerable extent. Issues of concern appeared to stem mostly from program execution, rather than program relevance. For instance, experts noted challenges engaging with industry and the perceived academic culture of NRC researchers.
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Profile of the HHT Portfolio
For 2013‑14, Footnote 39 HHT 's indirect expenditures represented 33.8% of total expenditures. This ratio comes close to meeting the 30% target set by NRC and was the lowest of the three life sciences portfolios. As part of the creation of the Portfolio and the development of program plans, HHT sought to focus its efforts on areas that are more likely to yield a strong impact for Canada.
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A few internal interviewees noted that this situation may result in lost business opportunities for HHT and the inability of NRC as a whole (including IRAP ) to best serve Canadian companies. As described in Section 2, portfolios are the business units responsible for managing people and facilities. Generally, internal interviewees believe that HHT has established the research competencies required to successfully deliver its three approved programs and, in turn, achieve its expected outcomes. A total of 46 stakeholders were consulted through the evaluation, including 17 internal stakeholders ( HHT management and staff, BMS staff and IRAP Industrial Technology Advisors), and 29 external stakeholders (see Table 4).
In addition to this amount, Zymeworks reported that it established a strategic collaboration with Merck & Co. While very few clients were able to attribute a specific amount to the work performed by HHT , most clients agreed that HHT 's contribution played an important, and even critical, role in their ability to access investment capital in support of their growth. The pharmaceutical/biopharmaceutical industry is important to the Canadian economy and HHT activities help to address some of the needs of biopharmaceutical SME s. HHT works with firms to accelerate the drug discovery process and de-risk the development of products, making the firms more attractive to funders.
For instance, representatives from the two life sciences industry associations, as well as the three prospective clients interviewed as part of the evaluation, had limited knowledge of the Portfolio. It is worth noting that even some clients commented that they are not fully aware of HHT 's service offerings. In this regard, many evaluation participants strongly emphasized the need to raise the profile and degree of visibility of HHT within the biopharmaceutical industry in order to further expand its reach.
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